Responsibilities

• Execute molecular biology experiments according to established protocols, including DNA/RNA purification, PCR, qPCR, gel electrophoresis, plasmid cloning and preparation, in vitro transcription, NGS library construction (pooling, cleanup, quantitation) and Western blotting
• Perform mammalian cell culture experiments such as transfection, transduction, electroporation, filtration, fluorescence microcopy and cell-based assays in a BSL-2 laboratory setting
• Provide technical supports for performing quality control experiments
• Review literature, design new experiments, analyse data, write SOPs and document research work
• Visualise and present data at regular team meetings
• Account for agreed experiment timelines
• Participate in discussion about research plan and direction
• Contribute to development of safer and more efficient delivery of therapeutic gene-editing agents
• Candidate with less experience will be considered as Associate Scientist

Requirements

• A Master’s degree (or Bachelor’s degree with at least one-year relevant lab experience) in life sciences, biomedical sciences, biochemistry, chemistry, microbiology or related discipline
• Experience in working with DNA, RNA and protein
• Hands-on experience in molecular cloning, PCR-based assays and mammalian cell culture
• Willingness to ask scientific questions, provide solutions to technical problems and learn new research methods

Preferred Requirements

• Experience in CRISPR (or other gene editors)
• Understanding and hands-on experience in working with nanoparticles and specimens of animal and human origins
• Experience in using R, ggplot2 and GraphPad Prism in statistical analysis and data visualisation.
• Adaptable to a fast-paced working environment

Position (full-time)

Senior Scientist (Bioinformatics) – CAS

Primary responsibilities

• Develop bioinformatic solutions for analysing large-scale genomic DNA sequencing data.
• Develop machine learning / AI-based models based on public and in-house generated large-scale data for predicting functional protein domain with desired genome editing feature.
• Overseeing and maintaining various bioinformatic pipelines.

Requirements

• A PhD degree in bioinformatics or biostatistics.
• Publications showing competence in bioinformatics is required.
• Able to accommodate a fast-paced working environment and a rapidly evolving R&D field.

Primary responsibilities

• Develop bioinformatic pipelines to analyze genomics DNA sequencing data.
• Assist in large-scale data and AI-based algorithm development in predicting protein structure and domain functions for deaired genome editing requirements.
• Assist in various pipeline and database maintenance

Requirements

• A recent master degree with at least 2 years working experience or a PhD in bioinformatics, computer science, or biostatistics disciplinary
• Publications showing competence in bioinformatics is required.
• General knowledge or experience in genomic DNA sequencing data analysis is required.